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Living Proof

Harry Connick Jr (Actor), Angie Harmon (Actor), Dan Ireland (Director) Rated:
NR
Format: DVD
4.7 out of 5 stars 501 ratings
IMDb6.8/10.0
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Format Color, Dolby, Multiple Formats, AC-3, NTSC, Widescreen, Subtitled
Contributor Vivienne Radkoff, Amanda Bynes, Amy Madigan, Bruce McKinnon, Dan Ireland, Bernadette Peters, Paula Cale, Swoosie Kurtz, Brandon Smith, Melissa Suzanne McBride, Jackson Hurst, Robert Bazell, Regina King, Tammy Blanchard, Angie Harmon, Tom Nowicki, Harry Connick Jr See more
Language English
Runtime 1 hour and 31 minutes
Color Color
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Product Description

Top-rated Lifetime movie! Dr. Dennis Slamon has reached a breakthrough in his career. He has helped to develop a new experimental drug called Herceptin, which he hopes will become a revolutionary treatment in the fight against breast cancer. However, when funding for his project is cut, Slamon must turn to philanthropists Lilly Tartikoff and Ron Perelman to help make his life's most important work a reality. With the backing of his new supporters, Slamon continues to perfect his treatment, but his new drug proves that while it has the ability to give life, it does not work for everyone. This gut-wrenching true story explores one doctor's difficult struggle to find a cancer treatment that can save thousands of lives while giving meaning to his own life.

Product details

  • Aspect Ratio ‏ : ‎ 1.78:1
  • Is Discontinued By Manufacturer ‏ : ‎ No
  • MPAA rating ‏ : ‎ NR (Not Rated)
  • Product Dimensions ‏ : ‎ 7.5 x 5.25 x 0.5 inches; 0.01 ounces
  • Item model number ‏ : ‎ 043396299122
  • Director ‏ : ‎ Dan Ireland
  • Media Format ‏ : ‎ Color, Dolby, Multiple Formats, AC-3, NTSC, Widescreen, Subtitled
  • Run time ‏ : ‎ 1 hour and 31 minutes
  • Actors ‏ : ‎ Harry Connick Jr, Angie Harmon, Amanda Bynes, Bernadette Peters, Swoosie Kurtz
  • Subtitles: ‏ : ‎ English, French
  • Studio ‏ : ‎ Sony Pictures Home Entertainment
  • ASIN ‏ : ‎ B001TKNWV4
  • Writers ‏ : ‎ Robert Bazell, Vivienne Radkoff
  • Customer Reviews:
    4.7 out of 5 stars 501 ratings

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4.7 out of 5 stars
501 global ratings

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Top reviews from the United States

  • Amanda
    5.0 out of 5 stars Must watch for anyone with Her 2 positive BC
    Reviewed in the United States on January 17, 2025
    Verified Purchase
    I watch this twice and cried twice.
    Herceptin has changed they way cancer is treated
    And has given so many people a chance to live cancer free or live so much longer with BC Mets.
    It truly is a life changing drug.
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  • Tom Brody
    5.0 out of 5 stars A first rate account of the financial, regulatory, and emotional burdens of drug-development.
    Reviewed in the United States on November 12, 2010
    Verified Purchase
    LIVING PROOF is a biographical account of Dr. Dennis Slamon's discovery and invention of a new class of oncology drugs and, in particular, trastuzumab (HER-2). Trastuzumab is an antibody used for curing breast cancer. First, let us look at the regulatory aspects of this film. Then, let us look at the emotional aspects of the movie.

    REGULATORY ASPECTS. The viewer will learn about inclusion criteria for a clinical trial. We learn that a subject must have breast cancer, and that the tumor cells must be HER2 positive. We learn that the goal of Phase I trials is to characterize safety ("side-effects"). We also learn about exclusion criteria from this movie, for example, the exclusion criterion of the study subject having had too many rounds of prior chemotherapy. This movie shows one of the characters being refused entry into the Phase II trial because she failed to satisfy this particular criterion. Also, we learn that funding for any particular clinical trial can be a start-and-stop activity. In this movie, we learn that where GENENTECH decided not to fund the study, another company, REVLON stepped in and provided money. Another take-home lesson, is that clinical trials require regulatory approval from the FDA, and that clinical trials need to be designed by physicians who actually have experience in trial design (just because you are a doctor who discovers a new drug does not mean that you have the slightest clue in trial design). The movie shows Dr. Shamon being told that "his" clinical trial will be taken over by physicians who actually have experience in trial design. Also, relating to concept of regulatory approval, we see a cancer victim who had been approved for entry into a Phase III trial, begging a receptionist to be given drug right away, "I only have a day to live, I need the drug right now, I can't wait until next week." We learn of the concept "quality of life," which is an issue for most clinical trials for chronic, debilitating diseases. Quality of life in these clinical trials is always measured by a special questionnaire called, "Health Related Quality of Life instrument." LIVING PROOF teaches us all of these lessons. These lessons, as taught by LIVING PROOF, can be understood by children of the ages 8-12, by teenagers, and by adults.

    EMOTIONAL ASPECTS. To cut to the chase, this movie requires a collection of Kleenex tissues or handkerchiefs. We see various examples of emotional dispair, where is woman is being denied entry into a clinical trial, because she does not meet the entry criteria (inclusion criteria). The result is that she dies leaving behind a family and children (Kleenex #1). Another character turns down a marriage proposal, because she believes that she will eventually die of her breast cancer (Kleenex #2). There are other scenes of emotional triumph, which also require the handkerchief. One of the characters has reached the point of despair, and decides to live out her final days in Mexico, sipping margueritas on a relaxing beach, instead of vomiting from chemotherapy. But then, she gets persuaded to enter Dr. Slamon's trial, and at the end of the movie, she is declared totally cancer-free (Kleenex #3, #4, and #5).

    THE BAD GUY. One unusually interesting theme in this story concerns an employee at Genentech known as "Reinhart." He is portrayed as the bad guy in this movie, apparently because of his expertise in trial design, in contrast to Dr. Slamon's lack of expertise in this skill. Even though it is not certain why "Reinhard" is the bad guy, any viewer of this movie will sense that something good has occurred when Reinhard is taken off of the trial. While I do not know if "Reinhard" corresponds to a real person, it is often the case that, in management, people with Reinhard-like characteristics are encountered. This particular Reinhard had characteristics that were both good and bad.

    SUMMARY. The movie sticks to events relating to the various phases of this drug -- research, funding, regulatory approval, enrollment, adverse drug reactions ("side effects"), trouble getting enough patients enrolled, and efficacy. The movie does disclose some of the outside activities of all the characters, for example, a courtship between an African-American woman and a Caucasian man (happy ending), Christmas party not attended by dead mother, and fact that Dr.Slamon did not have time to be a devoted "family man," that is, to attend school functions of his daughter. But these outside activities merely act as a cementing substance to the "bricks" of this movie, namely, the steps required to get regulatory approval. The movie emphasizes the issue of femininity, for example, where the soundtrack plays Dionne Warwick's, "I SAY A LITTLE PRAYER," at which point the film dwells on each cancer victim, that is, on her activities in grooming, lipstick, womanly shoes, skirts, and so on.

    CRITICISM. I only have one critisism. The movie does not mention that Phase II trials and Phase III trials are usually randomized (placebo versus study drug). However, it is quite possible that the HERCEPTIN clinical trials only contained one arm (study drug only). But it is also possible that the movie failed to mention randomization, in order not to scare away the viewers of this movie (to scare them away from participating in clinical trials). FIVE STARS for LIVING PROOF.
    10 people found this helpful
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  • Loves To Read
    5.0 out of 5 stars LIVING PROOF OF FAITH AND PERSEVERANCE!!
    Reviewed in the United States on December 26, 2009
    Verified Purchase
    This made for TV movie is based on the book, HER-2, which is the story of Dr. Dennis Slamon's passionate pursuit of a cure for breast cancer. It is essentially the battle between Slamon and Genentech, the company that owns the rights to Herceptin. Slamon is the lead research doctor on the drug and believes with all his being that it can give new life to at least 40,000 of the 200,000 new breast cancer cases each year. Genentech does not believe it has the potential to be financially successful, which is their definition of a successful drug (at least how it is pictured in the film). At a point in the development of the drug, Hollywood friends come to the rescue and raise the money to keep the project going. It is clearly Slamon's drive and passion that is keeping the research alive. It is also the general story of what it takes to bring a new drug to market through the FDA approval process-no insignificant task no matter how great your drug is. The film becomes very emotional as he finally wins approval to begin testing on women in stage IV breast cancer-those that are considered without hope from any approved treatments. Because of the extremely tight restrictions put in place by Genentech, he must exclude some women who are desperate for any hope of a cure. Even more heart wrenching are those who are helped in the Phase I testing but are not allowed to move to Phase II because of the Genentech restrictions. He also discovers that it helps some but not others which is powerfully visualized in a scene where the treatment room is shown full of the test patients that started and one by one those who have died disappear. The film is a testimony to the belief and perseverance of one man who was determined to make a difference against great odds. Where might that apply in our lives? While the drug is not without controversy today, it has saved thousands of lives and fulfilled Slamon's dream of making a difference in the battle against breast cancer. The one shortcoming in the movie is the depiction of Genentech as, more or less, the evil enemy of this dedicated doctor (which they may very well have been) but there is another side to every drug story. And that is that there are hundreds (maybe thousands) of potential drugs out there to cure all kinds of diseases and some are worthwhile and some are not. There is not enough money to find out if they all work and someone has to make the decisions of which ones to pursue and they all sound great in the development stage. Making those kind of life and death decisions requires the wisdom of Solomon, something very few people have. These decisions will only get more difficult as our population ages and the money shrinks to provide treatment for everyone for every disease. This is a wonderful, inspirational film worth watching.
    7 people found this helpful
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  • Miguel
    5.0 out of 5 stars Amazing movie!
    Reviewed in the United States on October 26, 2024
    Verified Purchase
    Great movie to learn more about the medicine process
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  • Kevin
    5.0 out of 5 stars Breast cancer survivors will appreciate this movie.
    Reviewed in the United States on May 20, 2024
    Verified Purchase
    My wife is a breast cancer survivor and this movie hit home for both of us. We are so thankful for the drugs that helped to save her life. In God We Trust!
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  • Allie
    4.0 out of 5 stars Important movie
    Reviewed in the United States on September 8, 2019
    Verified Purchase
    For someone who has had breast cancer, this story is painfully eye opening as it relates to all the foot dragging involved in pushing a very promising treatment plan forward so it can save lives. Made me hate all the politics, and greed, behind pharmaceutical companies even more. Grrrrr

    So glad there are researchers out there looking to find treatments for cancers. I only wish they could find a CURE for stage IV breast cancer.

    Please donate to metavivor.org instead or pouring money into the Komen foundation. We need to find a cure not raise awareness with pink ribbons and money that funds their (Komen) salaries.
    3 people found this helpful
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Top reviews from other countries

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  • Helen Ali
    5.0 out of 5 stars I love this movie
    Reviewed in Canada on November 8, 2019
    Verified Purchase
    very good, kind of tearjerking.
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  • 久保田英男
    4.0 out of 5 stars 感動した
    Reviewed in Japan on May 24, 2022
    Verified Purchase
    感動して涙が止まらなかったが吹き替え版もあればいいのに
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  • Helen O'neill
    5.0 out of 5 stars LIVING PROOF
    Reviewed in Australia on November 30, 2018
    Verified Purchase
    There is nothing I can say but thank you, the DVD arrived before the estimated time, was a good quality DVD and the movie was fabulous. Thank you for making this available for me.
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  • Konstanz
    5.0 out of 5 stars A good dramatization of the book.
    Reviewed in Canada on March 16, 2013
    Verified Purchase
    Must see for anyone reading the book, and/or anyone dealing with Her2 positive breast cancer. Thank god for Revlon stepping in to fund this research thats saved so many women's lives.
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  • ゆめ
    5.0 out of 5 stars 感動しました！
    Reviewed in Japan on November 6, 2013
    Verified Purchase
    安いお値段で購入させていただきましたが、本当に素晴らしいドラマで
    感動で・・・涙・・涙・・・でした！
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