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Frontline Plus Flea and Tick Treatment for Small Dogs Upto 5 to 22 lbs. 6 Treatments

4.4 4.4 out of 5 stars 46,663 ratings
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Purchase options and add-ons

Brand Frontline
Item Form Stick
Scent Unscented
Item Weight 1.6 ounces
Active Ingredients (S)-methoprene, Fipronil
Item Volume 9 Milliliters
Allergen Information Allergen-Free
Dog Breed Size Small
Age Range (Description) All Life Stages
UPC 717077006629 350604288008

About this item

  • Keep your dog protected from fleas & ticks all month long with FRONTLINE Plus for Dogs a fast-acting, waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease
  • Break the flea life cycle with FRONTLINE Plus, specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control
  • Trusted by pet owners for over 20 years, FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply with one monthly dose providing protection from fleas & ticks for a full 30 days
  • FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over, so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products
  • Treat all dogs or cats in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations
  • Subscribe & save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus
  • Subscribe & save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus

Additional Details

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From the brand


From the manufacturer

The most trusted name in flea and tick treatment, Frontline Plus for dogs is quick acting

Award-Winning Flea & Tick Protection

Frontline Plus was awarded brand of the year by O World Branding Awards

BRAND OF THE YEAR

From World Branding Awards 3 years in a row

Frontline Plus for Dogs treatment kills and protects against fleas, flea eggs and larvae

KILLS FLEAS, EGGS & LARVAE

Effectively breaking the flea lifecycle

Frontline Plus for Dogs works to kill ticks

KILLS TICKS

Including ticks that may transmit Lyme disease

Frontline Plus for Dogs flea and tick prevention also kills chewing lice

KILLS CHEWING LICE

That cause irritation, itchiness, and redness

The video showcases the product in use.The video guides you through product setup.The video compares multiple products.The video shows the product being unpacked.

The #1 Name in Flea & Tick Protection*

FRONTLINE Plus LG Dog

FRONTLINE Plus SM Dog

FRONTLINE Plus MED Dog

FRONTLINE Plus XL Dog

FRONTLINE Plus Cat

Customer Reviews
4.4 out of 5 stars 47,104
4.4 out of 5 stars 46,663
4.4 out of 5 stars 22,483
4.4 out of 5 stars 14,718
4.3 out of 5 stars 46,970
Price
$68.92 $68.92 $68.98 $68.92 $68.92
Recommended Pet Size
45 to 88 pounds 5 to 22 pounds 23 to 44 pounds 89 to 132 pounds Cats & kittens over 1.5 pounds
Kills Fleas, Eggs, & Larvae
Kills Ticks & Chewing Lice
Minimum Age of Pet
Dogs & puppies 8 weeks & older Dogs & puppies 8 weeks & older Dogs & puppies 8 weeks & older Dogs & puppies 8 weeks & older Cats & kittens 8 weeks & older
Available Sizes
3, 6 and 8-Dose 3, 6 and 8-Dose 3, 6 and 8-Dose 3, 6 and 8-Dose 3, 6 and 8-Dose
Do not use on cats Do not use on cats Do not use on cats Do not use on cats For use on cats only

Product guides and documents

Product details

  • Is Discontinued By Manufacturer ‏ : ‎ No
  • Product Dimensions ‏ : ‎ 5.75 x 1 x 4.5 inches; 1.6 ounces
  • Manufacturer recommended age ‏ : ‎ 1 month and up
  • Item model number ‏ : ‎ 74273
  • Department ‏ : ‎ Pet Supplies
  • Date First Available ‏ : ‎ September 2, 2004
  • Manufacturer ‏ : ‎ Boehringer Ingelheim Animal Health
  • ASIN ‏ : ‎ B0002J1FLW
  • Country of Origin ‏ : ‎ France
  • Customer Reviews:
    4.4 4.4 out of 5 stars 46,663 ratings

Product information

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Frontline Plus Flea and Tick Treatment for Small Dogs Upto 5 to 22 lbs. 6 Treatments


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Product Description

Keep your dog protected with the number 1 name in flea & tick protection (1), FRONTLINE. FRONTLINE Plus for Dogs is a fast-acting, long-lasting waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease. Break the flea life cycle — FRONTLINE Plus for Dogs is specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control. Trusted by pet owners for over 20 years (2) — FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply. Applied to a single point on your pet, the flea and tick control treatment covers your dog's entire body and deposits in the sebaceous glands. These glands act as a reservoir, continuously replenishing the treatment onto your pet, working even if your dog gets wet. Just one dose of FRONTLINE Plus each month protects against fleas & ticks for a full 30 days. FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products. Appropriately treat all pets in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations. Subscribe and save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus. Be sure to visit our brand store and follow us to stay up to date on new FRONTLINE products, features, tips and more. References: (1) BI Marketing Excellence Survey performed by Kynetec, November 2023. (2) 20 years of trust in killing fleas and ticks demonstrated by various studies in the past 20 years including a 2002 Pet Owner Brand Awareness and Attitude Tracking Study performed by Bruno and Ridgway Research Associates and the 2023 BrandSpark© American Trust Study where FRONTLINE Brand Products were voted most trusted for brand for flea & tick prevention.

Top Brand: Frontline

Highly Rated
100K+ customers rate items from this brand highly
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100K+ orders for this brand in past 3 months
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Important information

Safety Information

KEEP OUT OF REACH OF CHILDREN. WARNING: PRECAUTIONARY STATEMENTS - HAZARDS TO HUMANS: WARNING. Causes substantial but temporary eye injury. Do not get in eyes or on clothing. Avoid Contact with skin. Harmful if swallowed. Wash thoroughly with soap and water after handling and before eating, drinking, chewing gum, using tobacco or using the toilet. Remove and wash clothing that may have come in contact with the product before reuse. HAZARDS TO DOMESTIC ANIMALS: For external use on dogs ONLY. Do not use on animals other than dogs. Do not use on dogs under 9 weeks of age or weighing less than 5 lbs. Individual sensitivities may occur after using ANY pesticide product. Dogs may experience some temporary irritation at the site of product application. If signs of sensitivity occur, bathe your dog with mild soap or shampoo and rinse with large amounts of water. If signs of sensitivity occur and persist, contact a veterinarian immediately. If your dog has an unusual reaction to the initial application, consult a veterinarian before repeating application. Certain medications can interact with pesticides. Consult a veterinarian before using on medicated, debilitated, aged, pregnant or nursing dogs, or dogs known to be sensitive to pesticide products. Consult a veterinarian for guidance on use against Sarcoptes mites. This product is not a substitute for a prescribed heartworm preventative.nCall 1-888-637-4251, for assistance. PHYSICAL OR CHEMICAL HAZARDS: Do not allow this product to come in contact with an oxidizing agent, as a hazardous chemical reaction may occur Harmful if swallowed. Causes substantial but temporary eye injury. Do not get in eyes or on clothing. Avoid contact with skin. Wear (specify appropriate protective eyewear such as goggles, face shield, or safety glasses). Wash thoroughly with soap and water after handling and before eating, drinking, chewing gum, using tobacco or using the toilet. Remove and wash contaminated clothing before reuse.

Ingredients

Active Ingredient: fipronil 9.8%, (S)-methoprene) 8.8%Inert Ingredients: 81.4%

Directions

Directions for Use Step 1. To REMOVE Applicator: 1. Use scissors to separate one blister; 2. Use scissors to cut along dotted line; 3. Peel down foil to remove the applicator. Step 2. OPEN Applicator. Hold upright with foil side toward you and snap applicator tip. Step 3. APPLY FRONTLINE Plus. Part the dog’s hair between the shoulder blades. Place the applicator tip just above the skin and squeeze. Apply entire contents of the applicator in a single spot directly onto the dog’s skin. Do not apply on top of the hair coat. Avoid contact with treated area until dry. Do not allow your dog to ingest the product. Do not apply to dogs weighing less than 5 lbs. or younger than 8 weeks of age. Do not use more than one application per dog per month. Frequency Use monthly to control fleas and ticks. Do not reapply FRONTLINE Plus for 30 days.

Legal Disclaimer

Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product.

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Price-15% $68.92
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$89.98$75.86$54.99$79.98$59.98
Delivery
Get it as soon as Friday, Mar 14
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Customer Ratings
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Customer reviews

4.4 out of 5 stars
46,663 global ratings

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Customers say

Customers appreciate the product's ease of application, tick resistance, and protection level. However, opinions differ on its functionality, flea control, value for money, dog health, and scratching.

AI-generated from the text of customer reviews

252 customers mention "Ease of application"237 positive15 negative

Customers find the product easy to use and apply. They mention it has no smell and no unusual behavior from their dogs after application, and the impact is almost immediate.

"...The instructions are straightforward, and the liquid absorbs quickly without leaving any residue or odor on my dog’s coat...." Read more

"Super easy to use and apply. No smell, no unusual behavior from our dog afterwards...." Read more

"This product is easy to apply to a pet and has clear instructions." Read more

"Easy to use" Read more

181 customers mention "Tick resistance"143 positive38 negative

Customers appreciate the tick resistance of the pet pest control product. They say it keeps ticks and flees off their pets.

"I've been buying this one for years now. Never seen any flees. One occasion we did see a tick but she had just been out in the woods...." Read more

"...this, but after I put it on her last month, she was free of ticks the whole July" Read more

"...She’s limited with her outside time but no ticks!" Read more

"My fur baby no longer has ticks, no side effects. It gets the job done" Read more

140 customers mention "Protection level"116 positive24 negative

Customers appreciate the product's protection from fleas, ticks, and chiggers. They say it provides fair protection, works to protect their pets from regular pesky fleas and sand fleas, and is easy to use for lasting protection. The product is trusted and effective, lasting the entire month for protection and coverage.

"...It’s a must-have for any small dog owner who wants reliable protection. Highly recommend this product for keeping your pup safe and pest-free!" Read more

"...It is formulated with fipronil and (S)-methoprene, which are both safe and effective ingredients that have been approved by the EPA for use on..." Read more

"Protect your dogs from summer's tick and Fleas. So easy to use and worth every penny!" Read more

"Quality tested on an older dog! Super protection! Highly recommend!" Read more

3,066 customers mention "Functionality"1,691 positive1,375 negative

Customers have mixed opinions about the product's functionality. Some say it works well against flees and ticks, and is a good product. Others mention it doesn't work as well as it used to, doesn't work on ticks, and the flea collars are not as effective.

"...small dog weighs just under 20 pounds, and this specific size works perfectly for her...." Read more

"...It takes time to work. By month three, after the third application our flea problem was completely gone...." Read more

"Very effective for my dogs! No more ticks and fleas!" Read more

"...It's not working!!!" Read more

1,453 customers mention "Fleas"853 positive600 negative

Customers have mixed opinions about the fleas. Some say the drops work well and eliminate fleas within 24 hours. Others report that the fleas return after a few days or become resistant to the product.

"...just a day or two, I noticed a huge difference—no scratching, no signs of fleas, and she seems so much more comfortable...." Read more

"I put these on my 3 dogs and my chihuahua still has fleas!!!!!I'm mad because I ordered 2 packs of 3!!! It's not working!!!" Read more

"...manchester terrier is completely healthy and fine after usage, and pest free." Read more

"Very effective for my dogs! No more ticks and fleas!" Read more

1,417 customers mention "Value for money"716 positive701 negative

Customers have mixed opinions about the product's value for money. Some find it effective and good for the price, while others say it's costly for a product that doesn't work.

"Great product and price." Read more

"Not sure these products don't work like they use to. And cost so much." Read more

"Value for money" Read more

"...It may seem pricier than other products but 1) it works with a single application and 2)in my experience, one dose lasts several months...." Read more

402 customers mention "Dog health"277 positive125 negative

Customers have mixed opinions about the product's effect on their dogs. Some say it helps pets and doesn't seem to affect them. Others report side effects like lethargic or dry heaving dogs after a week of application. There are also complaints that it didn't eliminate fleas completely for some dogs.

"Frontline Plus has been a lifesaver for my little pup!..." Read more

"Super easy to use and apply. No smell, no unusual behavior from our dog afterwards...." Read more

"...Also, I did notice that after a week of application my dog would become lethargic and would dry heave often and I’m started to suspect that the flea..." Read more

"...review, as I guarantee it to be worth your time and the health and safety of your pet...." Read more

266 customers mention "Scratching"133 positive133 negative

Customers have different experiences with the product's effect on scratching. Some say it doesn't cause skin irritation and relieves itching. Others report that their dogs still scratch and bite. However, some customers mention a reduction in fleas and scratching.

"...Within just a day or two, I noticed a huge difference—no scratching, no signs of fleas, and she seems so much more comfortable...." Read more

"...The product seems to work decently. My animals still itch occasionally but I haven't ever found any ticks or fleas on them...." Read more

"...No more new bites on my dogs bellies and no more insane scratching. It works, just gradually (which is realistic anyhow)...." Read more

"...However, the flea population and scratching are both diminishing. We also had our house treated by a pest company so that might be a factor." Read more

Frontline Plus for Small Dogs
5 out of 5 stars
Frontline Plus for Small Dogs
Frontline Plus has been a lifesaver for my little pup! As a dog owner, keeping my furry friend protected from fleas, ticks, and other pests is a top priority, and this product delivers every time. My small dog weighs just under 20 pounds, and this specific size works perfectly for her.One of the things I love most is how easy it is to apply. The instructions are straightforward, and the liquid absorbs quickly without leaving any residue or odor on my dog’s coat. Within just a day or two, I noticed a huge difference—no scratching, no signs of fleas, and she seems so much more comfortable.What I really appreciate is the long-lasting protection. Knowing she’s covered for an entire month gives me peace of mind, especially when we go for walks in areas where ticks are common. I’ve also never had to deal with any side effects, which can be a concern with some flea treatments. She stays happy and healthy, and I stay worry-free.I’ve been using Frontline Plus for years, and it’s the only flea and tick treatment I trust. It’s a must-have for any small dog owner who wants reliable protection. Highly recommend this product for keeping your pup safe and pest-free!
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Top reviews from the United States

  • Reviewed in the United States on November 22, 2024
    Size: 3 countVerified Purchase
    Frontline Plus has been a lifesaver for my little pup! As a dog owner, keeping my furry friend protected from fleas, ticks, and other pests is a top priority, and this product delivers every time. My small dog weighs just under 20 pounds, and this specific size works perfectly for her.

    One of the things I love most is how easy it is to apply. The instructions are straightforward, and the liquid absorbs quickly without leaving any residue or odor on my dog’s coat. Within just a day or two, I noticed a huge difference—no scratching, no signs of fleas, and she seems so much more comfortable.

    What I really appreciate is the long-lasting protection. Knowing she’s covered for an entire month gives me peace of mind, especially when we go for walks in areas where ticks are common. I’ve also never had to deal with any side effects, which can be a concern with some flea treatments. She stays happy and healthy, and I stay worry-free.

    I’ve been using Frontline Plus for years, and it’s the only flea and tick treatment I trust. It’s a must-have for any small dog owner who wants reliable protection. Highly recommend this product for keeping your pup safe and pest-free!
    Customer image
    5.0 out of 5 stars
    Frontline Plus for Small Dogs

    Reviewed in the United States on November 22, 2024
    Frontline Plus has been a lifesaver for my little pup! As a dog owner, keeping my furry friend protected from fleas, ticks, and other pests is a top priority, and this product delivers every time. My small dog weighs just under 20 pounds, and this specific size works perfectly for her.

    One of the things I love most is how easy it is to apply. The instructions are straightforward, and the liquid absorbs quickly without leaving any residue or odor on my dog’s coat. Within just a day or two, I noticed a huge difference—no scratching, no signs of fleas, and she seems so much more comfortable.

    What I really appreciate is the long-lasting protection. Knowing she’s covered for an entire month gives me peace of mind, especially when we go for walks in areas where ticks are common. I’ve also never had to deal with any side effects, which can be a concern with some flea treatments. She stays happy and healthy, and I stay worry-free.

    I’ve been using Frontline Plus for years, and it’s the only flea and tick treatment I trust. It’s a must-have for any small dog owner who wants reliable protection. Highly recommend this product for keeping your pup safe and pest-free!
    Images in this review
    Customer image
    16 people found this helpful
    Report
  • Reviewed in the United States on April 12, 2024
    Size: 3 countVerified Purchase
    Super easy to use and apply. No smell, no unusual behavior from our dog afterwards. Keep in mind, this does not work immediately, and the instructions even state this fact. It takes time to work.

    By month three, after the third application our flea problem was completely gone.

    Before we started using this product the fleas has gotten so bad that they were in multiple areas of the house the dog had been. Using only this product and vacuuming and cleaning regularly completely eradicated the nuisance. Most importantly, our manchester terrier is completely healthy and fine after usage, and pest free.
    80 people found this helpful
    Report
  • Reviewed in the United States on March 1, 2025
    Size: 3 countVerified Purchase
    Very effective for my dogs! No more ticks and fleas!
  • Reviewed in the United States on September 28, 2024
    Size: 3 countVerified Purchase
    Pills are better
    7 people found this helpful
    Report
  • Reviewed in the United States on February 15, 2025
    Size: 6 countVerified Purchase
    Great product and price.
  • Reviewed in the United States on October 16, 2012
    Size: 3 countVerified Purchase
    This review may be quite lengthy, but as an Amazon consumer, I recommend that you thoroughly read and understand this review, as I guarantee it to be worth your time and the health and safety of your pet. Frontline Plus for Dogs when packaged and sold properly (by most Veterinarians and most reputable companies) works as it is described to work. For those instances, I would give the product a 5 star rating. But being that this is a consumer review of Frontline Plus for Dogs for the marketplace of Amazon, I would like to bring a particular experience that I became a victim of, to the attention of the consumer.

    Merial produces the product named Frontline Plus for Dogs (of various weights) for US consumers and for the consumers in International markets. Products produced for US distribution are EPA approved. Products for International markets, are not EPA approved. EPA, in this instance, stands for Environmental Protection Agency. This agency sets and enforces rules and standards that protect the environment and control pollution. If a manufacturer produces and distributes EPA and non EPA approved products, it seems like a safer option to administer the EPA approved product.

    Here goes the story of how I fell victim to a fraudulent sale of Frontline Plus for Dogs through a Seller / Store utilizing Amazon:

    Upon receipt of a Merial Frontline Plus for Dogs product from a Seller / Store on Amazon, the packaging appeared identical to those sold by my previous Veterinary purchase as well as a previous purchase of this product from Amazon directly. While the outside appeared legit, the inside contents had me on alert instantaneously. Here are a few of the red flags that came to mind: 1) The inside contents did not contain the stickers for the consumer to mark their calendar on usage dates. 2) The back of the sealed vials stated the product as Frontline Combo and not as Frontline Plus for Dogs. 3) The back of the sealed vials displayed three rows of orange that read as follows: "AD US. VET - USAGE VETERINAIRE - FOR VETERINARY USE." 4) The plastic vials contained a pull like backing as opposed to the difficult plastic tab opening that most consumers avoid and end up puncturing the seal to pull the vial from the individual packaging. 5) The sealed area of each vial shows individually, Fipronil 10% w/v, MethroPrene 9% w/v, and 0.67 ml. (I do not recall my previous vials ever showing these figures) 6) The lot number that can be found on the outside of the box contains a lot number that is different from the lot number listed on the back of each of the inside vials.

    I made the decision to not use this product on my pet and contacted the US 800 number for Merial, the manufacturer. After explaining the item that arrived to the representative, I was provided some interesting information that confirmed that my intuition of the product I received was correct and that this product was non-other than a fraudulent product that needed to be returned to the Seller / Store that sold this item to me through the use of Amazon. I gathered the following information from the representative at Merial: 1) The box is a US EPA approved Frontline Plus for Dogs. 2) The contents are not EPA approved as it contained vials for a different country. 3) The lot numbers on the box and vials are not consistent, when they should be. This product that I fell victim to was a foreign label product and when questioning the representative as to what she would do if she had this item on hand, she said that she would not use the item and request a refund because foreign label products are not EPA approved.

    So, as the title of my review states, "Buyer Beware", please beware and pay close attention to the product that you are receiving. If key points that I have listed in my review clearly identify your item that you received as a foreign label product, please contact the Seller / Store and request to process the return of the item immediately. Pets are like family, the last thing that I believe you should administer to your pet is a non EPA approved product.

    Additionally, if a consumer is sold a counterfeit / fraudulent item through Amazon's Marketplace, the consumer should report it to Amazon. These fraudulent Sellers / Stores don't belong on Amazon and the only way that we can initiate an investigation and seek their removal is to report each counterfeit situation to the attention of Amazon directly and warn potential consumers of these fraudulent Sellers / Stores.

    I had some issues initially handling my return with the Seller. I refused to pay to ship the counterfeit / fraudulent items (that shouldn't have been sold to me in the first place) back and I insisted that the Seller either pay for the postage and tracking of the products or refund it to me with the refund of my original purchase (Including my original shipping costs). The Seller after multiple email communications emailed me a prepaid USPS mailing label with tracking.

    I was hesitant on naming the fraudulent Amazon Marketplace Seller / Store until my entire return was processed and refunded. Now that my refund was successful, the fraudulent Frontline Plus that was sold to me was sold through the Amazon Marketplace Seller / Store of Discount Flea. The return address company name was Doc's Discount Flea Control located in Las Vegas, NV. The front of their sold product contains a sticker that refers you to re-order from unitedpetmeds2010.com with a 10% discount off of an order of $100 or more. I do not recommend purchasing these products from any of these companies. I would also be wary of any other company that you receive items that look as I described and suggest requesting an immediate return and issuing a complaint to Amazon of the fraudulent Seller / Store that you encountered.
    253 people found this helpful
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  • Reviewed in the United States on January 31, 2025
    Size: 3 countVerified Purchase
    My Chihuahua is very picky and he refuses to eat treats with flea prevention medicine. I’ve been using this for years on my almost 18 year-old Chihuahua. It keeps the fleas away if I make sure to keep up with his monthly regimen and it doesn’t cause him any type of allergic reactions. I will continue to use this religiously.
    3 people found this helpful
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  • Reviewed in the United States on December 3, 2024
    Size: 3 countVerified Purchase
    Not sure these products don't work like they use to. And cost so much.
    3 people found this helpful
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Top reviews from other countries

  • juan michelangeli
    5.0 out of 5 stars Great product
    Reviewed in Saudi Arabia on October 10, 2024
    Size: 3 countVerified Purchase
    My order was delivered on time!