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Heterocyclic Chemistry 5th Edition

4.7 out of 5 stars 44 ratings

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This book has so closely matched the requirements of its readership over the years that it has become the first choice for chemists worldwide.

Heterocyclic chemistry comprises at least half of all organic chemistry research worldwide. In particular, the vast majority of organic work done in the pharmaceutical and agrochemical industries is heterocyclic chemistry.

The fifth edition of Heterocyclic Chemistry maintains the principal objective of earlier editions – to teach the fundamentals of heterocyclic reactivity and synthesis in a way that is understandable to second- and third-year undergraduate chemistry students. The inclusion of more advanced and current material also makes the book a valuable reference text for postgraduate taught courses, postgraduate researchers, and chemists at all levels working with heterocyclic compounds in industry.

Fully updated and expanded to reflect important 21st century advances, the fifth edition of this classic text includes the following innovations:

  • Extensive use of colour to highlight changes in structure and bonding during reactions
  • Entirely new chapters on organometallic heterocyclic chemistry, heterocyclic natural products, especially in biochemical processes, and heterocycles in medicine
  • New sections focusing on heterocyclic fluorine compounds, isotopically labeled heterocycles, and solid-phase chemistry, microwave heating and flow reactors in the heterocyclic context

Essential teaching material in the early chapters is followed by short chapters throughout the text which capture the essence of heterocyclic reactivity in concise resumés suitable as introductions or summaries, for example for examination preparation. Detailed, systematic discussions cover the reactivity and synthesis of all the important heterocyclic systems. Original references and references to reviews are given throughout the text, vital for postgraduate teaching and for research scientists. Problems, divided into straightforward revision exercises, and more challenging questions (with solutions available online), help the reader to understand and apply the principles of heterocyclic reactivity and synthesis.

Editorial Reviews

Review

“Overall, this book is recommended as a text for undergraduate and more advanced students on this pervasive, important, and underappreciated topic in chemistry.” (Journal of Chemical Education, 1 October 2012)

"This excellent book is well written, heavily referenced, and thoroughly indexed. Accordingly, it serves as both an instructional heterocyclic chemistry textbook and a portal to the primary synthetic chemistry literature." (Journal of Medicinal Chemistry, 2011)

"My favourite chapter is the organometallic chemistry that presents an up-to-date treatment of the topic and helps confirms a colleague's observation that ‘With today's techniques one can be convinced that a modern organic chemist can make any small molecule he or she desires.' I particularly like the treatment of the concatenation of five-membered ring systems, an increasingly important area in medicinal chemistry. This chapter proves a real ‘coup de grace'." (Reviews, December 2010)

"In summary, Heterocyclic Chemistry by Joule and Mills is in a class of its own and can be thoroughly recommended as supplementary reading for undergraduate courses and as a first port of call for researchers seeking a quick entry to the extensive heterocyclic literature." (Applied Organometallic Chemistry, 2010)

"My recommendation is, even if you already have the 4th edition, to buy the latest version. At only £39.95 for the paperback version this is outstanding value for money." (Organic Process Research & Development Journal, 2010)

From the Inside Flap

Heterocyclic chemistry is a central part of organic chemistry and biochemistry. The term refers to a particular set of chemical structure characteristics, with many drugs and specialty chemicals, and most agrochemicals, containing these characteristics. Heterocyclic Chemistry by Joule & Mills has established itself as the premier textbook of heterocyclic chemistry, used by high level undergraduates, postgraduates and industrial researchers all over the world.


Heterocyclic Chemistry covers the fundamentals of heterocyclic reactivity and synthesis in a way that is understandable to second- and third-year undergraduate chemistry students. It also includes more advanced material, making the book appropriate for postgraduate taught courses and to researchers, either at postgraduate degree level or those working with heterocyclic compounds in industry. Essential teaching material is collected in specific introductory chapters, explaining the principles of heterocyclic reactivity in the simplest terms, suitable either as introductions or as summaries for examination preparation. These chapters are augmented by detailed, systematic discussions of the chemical reactivity of particular heterocyclic systems. References to both primary literature and reviews are given throughout the text, and whilst these are essential for postgraduate teaching and to research workers, they do not interfere with the readability of the text for undergraduate students.

Product details

  • Publisher ‏ : ‎ Wiley-Blackwell; 5th edition (June 1, 2010)
  • Language ‏ : ‎ English
  • Paperback ‏ : ‎ 720 pages
  • ISBN-10 ‏ : ‎ 1405133007
  • ISBN-13 ‏ : ‎ 978-1405133005
  • Item Weight ‏ : ‎ 3.74 pounds
  • Dimensions ‏ : ‎ 7.5 x 1.4 x 9.7 inches
  • Customer Reviews:
    4.7 out of 5 stars 44 ratings

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Top reviews from the United States

  • Reviewed in the United States on December 3, 2011
    I'm a chemist by education, trade, and love for the art. Although I hardly ever work with heterocyclic compounds aside from the occasional pyridine I have always been fascinated by them. This book gives a good overview of a number of systems complete with some reactions of them and their synthesis. All of this is presented in a very concise format that allows the casual reader to read the book for enjoyment without getting bogged down. I'm sure many of you out there know the feeling of reading a few paragraphs of information and then to be given several 'dry' paragraphs of one literature reaction after another. There are few if any actual detailed procedures in this book, it's overview and if you have the background that's what makes it fun.
    2 people found this helpful
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  • Reviewed in the United States on October 18, 2017
    Excellent book to study heterocyclic chemistry
  • Reviewed in the United States on March 27, 2018
    love it
  • Reviewed in the United States on November 28, 2014
    It's a very good book. My boyfriend really like it~
  • Reviewed in the United States on September 15, 2011
    The book was exactly as it was described and it did not take more than a week for it to arrive.
  • Reviewed in the United States on June 10, 2015
    great textbook, very useful
  • Reviewed in the United States on January 3, 2013
    I bought this book because it was required for a medicinal chemistry course. We were required to read almost the entire text so it sort of flew by. It seemed a little fast at first, but you see that after introducing a lot of concepts in the first few chapters, the rest of the book simply covers the same topics in greater detail. The book was extremely dry reading and although I don't love it, I elected not to sell it back because it is a good reference that I may actually use later, it also contains journal citations for most methods mentioned in the text.
    One person found this helpful
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  • Reviewed in the United States on June 26, 2014
    it came as advertised

Top reviews from other countries

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  • Cliente Amazon
    5.0 out of 5 stars Ottimo pezzo
    Reviewed in Italy on July 23, 2020
    Testo da avere sempre a portata di mano per la didattica, se si devono preparare esami é molto utile per avere/completare una preparazione di base. È ben fatto, ha una struttura chiara e ricorrente in ogni capitolo che permette di fare chiarezza, ovviamente non c'è tutto ma l'essenziale è presente (in chimica non ci sono mai libri con dentro tutto). Utile anche dopo un esame per approfondire e studiare argomenti non trattati a lezione
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  • Shanghai Tang
    5.0 out of 5 stars A textbook for CRO scientists
    Reviewed in the United Kingdom on January 24, 2020
    We have >1000 process chemists, so I use this book to train their knowlage of heterocyclic chemistry, we like it
  • imran
    5.0 out of 5 stars Excellent at Post graduation level
    Reviewed in India on January 17, 2019
    Best book in heterocyclic chemistry, recommended at Post graduation level
  • Ressah
    5.0 out of 5 stars Buen libro, envío rápido.
    Reviewed in Mexico on January 6, 2021
    A pesar de ser usado venía en muy buenas condiciones el libro así como las páginas del mismo excepto por los bordes de la portada levemente dañados, por lo cual no fue un problema pues poniendo plástico protector todo quedó bastante bien, y el libro es excelente y considero que muy bueno para los temas de orgánica para la IChO.
  • RGJ
    5.0 out of 5 stars Syntheses involving heterocyclic compounds.
    Reviewed in Canada on December 8, 2016
    This is the 5th Edition, so you know it is popular. The book focuses mostly on synthesis. There is not very much physical chemistry of heterocyclic compounds in the book. Still the book covers many compounds. It is geared towards pharmaceuticals, as you might expect.