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Ion Channels of Excitable Membranes 3rd Edition

by Bertil Hille (Author)
4.7 4.7 out of 5 stars 56 ratings
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Ion channels underlie a broad range of the most basic biological processes, from excitation and signaling to secretion and absorption. Like enzymes, they are diverse and ubiquitous macromolecular catalysts with high substrate specificity and subject to strong regulation. This fully revised and expanded third edition of Ion Channels of Excitable Membranes describes the known channels and their physiological functions, then develops the conceptual background needed to understand their architecture and molecular mechanisms of operation. It includes new chapters on calcium signaling, structural biology, and molecular biology and genomics. Ion Channels of Excitable Membranes begins with the classical biophysical work of Hodgkin and Huxley, continues with the roles of channels in cellular signaling, then develops the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, and molecular diversity, and ends with a discussion of channel evolution. Ion Channels of Excitable Membranes is written to be accessible and interesting to life scientists and physical scientists of all kinds. It introduces all the concepts that a graduate student should be aware of but is also effective in advanced undergraduate courses. It has long been the recognized authoritative overview of this field used by all neuroscientists.
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  1. ISBN-10
    0878933212
  2. ISBN-13
    978-0878933211
  3. Edition
    3rd
  4. Publisher
    Sinauer Associates is an imprint of Oxford University Press
  5. Publication date
    July 16, 2001
  6. Language
    English
  7. Dimensions
    9.48 x 1.4 x 8.04 inches
  8. Print length
    816 pages
  9. See all details
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Editorial Reviews

Review

"The third edition of Ion Channels of Excitable Membranes is markedly expanded, remarkably up to date, and stands as an unmitigated tour de force. Complete and enthusiastic, but not overwhelming, the text builds intuitively from the biophysical roots of the discipline. By maintaining a historical flavor, the reader is cleanly offered the essential ideas and concepts that remain key even as the field evolves. The book remains a resource for practitioners of the craft and the essential guide to the electrophysiological universe."
--Steven A. N. Goldstein, Cell

Book Description

An authoritative overview used by all neuroscientists

Product details

  • Publisher ‏ : ‎ Sinauer Associates is an imprint of Oxford University Press; 3rd edition (July 16, 2001)
  • Language ‏ : ‎ English
  • Hardcover ‏ : ‎ 816 pages
  • ISBN-10 ‏ : ‎ 0878933212
  • ISBN-13 ‏ : ‎ 978-0878933211
  • Item Weight ‏ : ‎ 3.36 pounds
  • Dimensions ‏ : ‎ 9.48 x 1.4 x 8.04 inches
  • Customer Reviews:
    4.7 4.7 out of 5 stars 56 ratings

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Bertil Hille

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4.7 out of 5 stars
56 global ratings

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Customers say

Customers find the book's content thorough and a great reference. They describe the writing style as lucid and readable for those with an introduction to neuroscience. However, some readers feel the style is dry and dense.

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Specialized contentPacing
13 customers mention "Specialized content"13 positive0 negative

Customers find the book's content thorough and a great resource for studying ion channels. They find it an excellent reference and introduction to biomath, providing good instruction on channel function.

"If you are interested in the science of electrophysiology, this is your textbook. Starts with basic, ground concepts and works it way up...." Read more

"Great book. So many details. It’s a wonderful world of ion channels." Read more

"com'mon man. its hille! Absolute necessity for any serious neurophysiologist. Although most people use this as a reference, I read cover to cover...." Read more

"...will find this book of much value as a resource and reference for those studying cellular action, function and response...." Read more

4 customers mention "Pacing"4 positive0 negative

Customers find the book well-written with a clear style. However, some find the writing dry and dense.

"...But for anyone involved in patch clamping, this is a must read." Read more

"...Very readable for someone who has had intro to neuroscience and some Bio background." Read more

"...The style is dry and dense; this is not a book that one reads multiple chapters at a time, but it will be helpful to have on the shelf to look up..." Read more

"The definitive textbook on this topic. Wonderfully written with a lucid style." Read more

Top reviews from the United States

  • Tricia A. Hardt
    5.0 out of 5 stars A staple of electrophysiology
    Reviewed in the United States on February 12, 2011
    Verified Purchase
    If you are interested in the science of electrophysiology, this is your textbook. Starts with basic, ground concepts and works it way up. Begin with an intro of Ohm's law, etc. and the history of electrophysiology and moves to more in depth material for each ion channel. The only drawback is that this is the most up to date version, so there has been some progress since then. But for anyone involved in patch clamping, this is a must read.
    2 people found this helpful
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  • Kamran
    5.0 out of 5 stars Everything you ever wanted to know about ion channels but were afraid to ask
    Reviewed in the United States on September 16, 2021
    Verified Purchase
    Great book. So many details. It’s a wonderful world of ion channels.
    Helpful
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  • mike
    5.0 out of 5 stars com'mon man. its hille! Absolute necessity for any serious neurophysiologist. Although most people use this as a reference, I re
    Reviewed in the United States on December 17, 2015
    Verified Purchase
    com'mon man. its hille! Absolute necessity for any serious neurophysiologist. Although most people use this as a reference, I read cover to cover. Very readable for someone who has had intro to neuroscience and some Bio background.
    One person found this helpful
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  • Ricardo Gómez
    5.0 out of 5 stars Genial
    Reviewed in the United States on January 25, 2022
    Verified Purchase
    Tenía las dos ediciones anteriores de este libro, pero andaba buscando la última edición. El estado del libro correspondía a la descripción del vendedor. Todo perfecto.
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  • thomas ward
    5.0 out of 5 stars great resource and reference book.
    Reviewed in the United States on August 29, 2011
    Verified Purchase
    The scientist and researcher will find this book of much value as a resource and reference for those studying cellular action, function and response. The book cites many examples of high quality data that are currently pertinent to many avenues of advanced cellular research areas.
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  • JTC
    4.0 out of 5 stars A good resource, though quite dry
    Reviewed in the United States on February 26, 2013
    Verified Purchase
    If you're thinking of learning about electrophysiology (not cardiac), this is THE resource. It discusses most of the known ion fluctuations and gives a great deal of background in the proper physics to aid understanding. The style is dry and dense; this is not a book that one reads multiple chapters at a time, but it will be helpful to have on the shelf to look up some information quickly. I took off a star because, as good and highly recommended a resource as this is, it's less practical than other books on electrophysiology. This is a 'before the experiment' book-it helps identify the channels you're looking at, what kind of glass to choose, what drugs might be appropriate for your experiment. It is less helpful with the 'during the experiment' questions than, say, Patch Clamping. It doesn't explain as well what a good seal looks like on your oscilloscope, for instance.

    To sum: great resource for electrophysiologists, pair with another book for the practical side of actually performing the experiment.
    4 people found this helpful
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  • Pita
    5.0 out of 5 stars Excelente. The best
    Reviewed in the United States on October 27, 2022
    Verified Purchase
    Perfect product
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  • Syh
    5.0 out of 5 stars Good book
    Reviewed in the United States on June 3, 2014
    Verified Purchase
    I don't think I need to comment on the book itself. It's quite specialized. Those who need it know how good it is.
    The book I got looks pretty much new. Just as described.
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Top reviews from other countries

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  • Ricardo Zavala
    5.0 out of 5 stars Electrofisiología
    Reviewed in Mexico on November 26, 2018
    Verified Purchase
    Si estás iniciando a estudiar electrofisiología de manera seria este es un excelente libro para iniciar. Claro, y bastante agradable de leer.

    Llegó en perfectas condiciones como siempre de Amazon.
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    Ricardo Zavala
    5.0 out of 5 stars
    Electrofisiología

    Reviewed in Mexico on November 26, 2018
    Si estás iniciando a estudiar electrofisiología de manera seria este es un excelente libro para iniciar. Claro, y bastante agradable de leer.

    Llegó en perfectas condiciones como siempre de Amazon.
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  • 馬場　洋
    5.0 out of 5 stars 歴史的な本
    Reviewed in Japan on January 29, 2024
    Verified Purchase
    長年待ってやっと手に入れました。今となってはこの本の内容はどこかから入手することができるでしょう。ただし、著者の年齢から考えて次の版はないはずです。電気生理学者にとってこの本は内容と言うよりは所有していることに意義があります。ネーヤーとザックマンの「Single-Channel Recording」のように、この本も歴史的に重要な位置づけになると思います。専門家以外には意味のないことかも知れませんが。
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  • LIU, HAN WEN GEORGE
    5.0 out of 5 stars Five Stars
    Reviewed in the United Kingdom on January 30, 2017
    Verified Purchase
    Thanks. Received the book as described.
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  • Kyu Ho Park
    5.0 out of 5 stars Un livre de référence
    Reviewed in France on October 13, 2004
    Verified Purchase
    "Ion channels of excitable membranes" est un livre de référence pour ceux qui s'intéressent au domaine des canaux ioniques. Cette nouvelle édition paraît au moment où les protéines membranaires remobilisent l'intérêt des biologistes. Plus particulièrement, plusieurs membres la famille des canaux ioniques ont leur structure tridimensionnelle résolue à l'échelle atomique!
    Report
  • cygnusx11
    5.0 out of 5 stars Very useful text book Gianluigi Zangari del Balzo
    Reviewed in the United Kingdom on January 11, 2015
    Verified Purchase
    Very useful text book
    Gianluigi Zangari del Balzo, theoretical physicist, the "NOUS" project
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