
Enjoy fast, free delivery, exclusive deals, and award-winning movies & TV shows with Prime
Try Prime
and start saving today with fast, free delivery
Amazon Prime includes:
Fast, FREE Delivery is available to Prime members. To join, select "Try Amazon Prime and start saving today with Fast, FREE Delivery" below the Add to Cart button.
Amazon Prime members enjoy:- Cardmembers earn 5% Back at Amazon.com with a Prime Credit Card.
- Unlimited Free Two-Day Delivery
- Streaming of thousands of movies and TV shows with limited ads on Prime Video.
- A Kindle book to borrow for free each month - with no due dates
- Listen to over 2 million songs and hundreds of playlists
- Unlimited photo storage with anywhere access
Important: Your credit card will NOT be charged when you start your free trial or if you cancel during the trial period. If you're happy with Amazon Prime, do nothing. At the end of the free trial, your membership will automatically upgrade to a monthly membership.
Buy new:
-15% $16.95$16.95
Ships from: Amazon.com Sold by: Amazon.com
Save with Used - Good
$5.01$5.01
Ships from: Amazon Sold by: GreatBookDealz

Download the free Kindle app and start reading Kindle books instantly on your smartphone, tablet, or computer - no Kindle device required.
Read instantly on your browser with Kindle for Web.
Using your mobile phone camera - scan the code below and download the Kindle app.
Change of Heart: Unraveling the Mysteries of Cardiovascular Disease Paperback – February 14, 2006
Purchase options and add-ons
- Print length258 pages
- LanguageEnglish
- Publication dateFebruary 14, 2006
- Dimensions5.19 x 0.62 x 8 inches
- ISBN-100375727043
- ISBN-13978-0375727047
Book recommendations, author interviews, editors' picks, and more. Read it now
Customers who viewed this item also viewed
Editorial Reviews
Review
“This book holds many lessons for the present. . . . A Change of Heart is an easy but exciting read. We owe a lot to Framingham.” –Nature
"This account of the Framingham study . . . does justice to the courage and commitment of both the medical scientists and the patients who contributed so much to advancing the field of cardiology." –The Boston Globe
“The Framingham Heart Study contributed considerable evidence about the important risk factors for cardiovascular disease, effective lifestyle adjustments, and preventative steps. . . . Scattered through the book are important lessons for the prevention of heart disease. . . . An engaging account.”–Science
About the Author
Excerpt. © Reprinted by permission. All rights reserved.
Product details
- Publisher : Vintage (February 14, 2006)
- Language : English
- Paperback : 258 pages
- ISBN-10 : 0375727043
- ISBN-13 : 978-0375727047
- Item Weight : 7.2 ounces
- Dimensions : 5.19 x 0.62 x 8 inches
- Best Sellers Rank: #2,367,450 in Books (See Top 100 in Books)
- #1,426 in Cardiology (Books)
- #1,431 in Cardiovascular Diseases (Books)
- #2,595 in Anatomy (Books)
- Customer Reviews:
About the author

Discover more of the author’s books, see similar authors, read book recommendations and more.
Customer reviews
Customer Reviews, including Product Star Ratings help customers to learn more about the product and decide whether it is the right product for them.
To calculate the overall star rating and percentage breakdown by star, we don’t use a simple average. Instead, our system considers things like how recent a review is and if the reviewer bought the item on Amazon. It also analyzed reviews to verify trustworthiness.
Learn more how customers reviews work on AmazonTop reviews from the United States
There was a problem filtering reviews. Please reload the page.
- Reviewed in the United States on December 30, 2010I heard of the Framingham Heart Study (FHS) long ago, and I was interested enough to have studied some of the data from it as an undergraduate in Statistics many years ago, and later while in graduate school in Statistics. After that, I didn't think of FHS again until the other month, when representatives of a "boot-camp" style fitness fad were knocking it (along with the Harvard Nurses study) as deeply flawed, having no conclusions, only observational, etc. I've always heard FHS was top notch, but maybe I didn't look at it close enough in the past to see serious flaws.
After doing medical journal searches online and reading some interesting studies, I looked here for a more breezy read, and found this great book. This book is a well-written page turner, covering the personalities, the thoughts at certain periods in history, and the science of FHS. From it, I have concluded that FHS is an embarrassment - of riches. Conclusions from a fitness fad aren't legitimate conclusions - you need to have science to make those.
Thank you project managers, scientists, authors, and thank thank thank thank thank you to the thousands of men and women, their children, and grandchildren for donating their time and letting us take a glimpse at your lives. Making the world a better place sounds so cheesy and overdone, but words fail me here.
- Reviewed in the United States on December 12, 2024“A Change of Heart: How the People of Framingham, Massachusetts, Helped Unravel the Mysteries of Cardiovascular Disease,” by Daniel Levy and Susan Brink, Knopf, NY, 2005. This 258-page hardback tells of the famous Framingham Study of 1948, which tracked the health of participants for 50 years to identify causes of heart disease. The study revealed the risks associated with smoking, high blood pressure, diabetes, and especially cholesterol. Women were thought immune to heart disease. By-pass surgery and angioplasty evolved as treatments for clogged arteries. Electrocardiogram, echocardiogram, and stress testing on a treadmill became available to assist in diagnosis.
Before the Framingham study, high blood pressure was due to aging and was thought necessary to push blood through aging arteries. The ideal was your age plus 100. That was fine for young people but disaster for seniors. FDR suffered from high blood pressure. (In 1944, his blood pressure was recorded as 226/118.) He died of a stroke. His blood pressure was considered normal and went untreated. Few treatments were available. Antibiotics and vaccines greatly reduced childhood death. Twenty years after FDR’s death childhood mortality rates dropped by 87%. Heart disease became a leading cause of death.
Vannevar Bush, director of the Office of Scientific Research and Development, urged President Truman to make medical research a national priority. Congress created the National Heart Institute in 1948. A $500K grant to NIH as seed money for the Framingham study soon followed.
Life styles changed after WWII. Rosy Riveter returned home from defense plants to don aprons and serve high-fat diets. We transitioned from lean meats (from free roaming livestock) to tender marbled steak from sedentary livestock. Rationing was over. Homeowners added power lawn mowers and electric vacuum cleaners. Most owned an automobile. Women caught up on smoking rates. From France data suggested moderate amounts of wine reduced risk.
In 1900, diseases of the heart was the fourth leading cause of death. The rate was 137/100,000 in 1900; 260 at the start of the Framingham study; 340 at its peak in 1970; and 200 in 2003.
Plaque in the arteries was found in cadaver aortas in the 18th century. Chest pain, angina pectoris, was first described in 1768. Plaque is primarily esters of cholesterol. Heart attack or myocardial infarction caused by blockage of arteries to the heart was first described in 1912. Heart attack was thought to always be fatal. Electrocardigram to detect the heart’s electrical signals was first discovered in 1902 and became a tool in 1914. The American Heart Association was founded in 1924.
Ancel Keys began studies of diet after noting that heart attack rates varied widely in nations with different diets. In 1951, he noticed that Spaniards and Italians had less cholesterol in their blood and less fat in their diets. Rates were low in Japan, high in Finland, and high among wealthy men in Italy. His observations resulted in the Seven Countries Study. They studied 12,770 men. After five years there were 588 deaths, 158 from heart disease. In the US 62 of 125 deaths were due to heart disease, in Finland 11 of 38, in Netherlands 16 of 50. In the other groups only one in eight deaths were due to heart disease. Diet was the major difference.
Framingham was selected for the study as a typical middle class community with a background as a farm community that became a small city. It was convenient to Harvard and other universities. It had a college, a hospital, and included teachers, doctors, lawyers and some who commuted to Boston.
The study hoped to sign up 5000 residents as participants. They expected 400 to have heart disease by the fifth year, 900 by the tenth year, and 1500 when the study was to end after 20 years. Participants got a detailed examination every other year. They were 30 to 59 years old when accepted. The study looked at 28 factors including sex, family history, hypertension, ulcers, colitis, diabetes, smoking, drinking, inadequate sleep, obesity, sedentary life style, and cholesterol. The study produced reams of data. They had IBM punched cards that could be sorted. Contact info was in a rolodex.
The first results were published in 1957. Heart disease was two to three times higher in men than women. Women had high rates of angina. In thirteen of the forty-three men who died of heart disease, coronary death was the first and only symptom. Half of those with heart attack died; one third of them suddenly. Higher blood pressure gave increased risk of heart disease. Escalating cholesterol numbers contributed. Results of the first six years was published in 1961–causing a change in medical practice and attitudes on health.
The authors report a typical scenario in acceptance of risk factors. When first reported its always bunk but gradually it gets accepted. Findings released to the Middlesex News often got published first and helped Framingham develop its image for research.
In 1968, the twenty years planned for the study was reached and NIH tried to shut it down. Roy Dawber of the staff moved to Boston University where he got funding to continue. When the news media heard of plans to discontinue, letters poured in, and Senators Kennedy and Proxmire came forward to support it. President Nixon agreed. Joint sponsorship with donors let Boston University continue as a partner.
In the 1940s, Dr. John Gofman at UC Berkeley used an ultra centrifuge to measure “bad” LDL and “good” HDL cholesterol. High levels of HDL cholesterol reduced risk of heart disease. Drugs to increase HDL are under development. Most heart attacks occur at moderate blood pressure, say 140/90.
As the study continued new aspects were begun. The children of participants were added to evaluate generational aspects. Computers and formal statistics arrived in 1983. Echocardiograms could identify heart disease sooner. Studies of minorities were added in the 1980s. Treadmill tests were added. Thickening of the heart muscle increased risk of heart disease and sudden death. Echocardiogram could predict atrial fibrillation, a dangerous heart rhythm disturbance. Atrial fibrillation increased the risk of stroke five fold.
A chapter describes the efforts to control blood pressure. The Framingham study first identified high blood pressure as a risk in 1957. Ed Fries at the Veterans Administration soon showed that treating high blood pressure reduced risk. He used chlorothiazide, a diuretic, one of the few drugs without side effects. Reduction to 130/85 was considered ideal. Acceptance of treatment was slow. As late as 1967, medical textbooks continued to recommend against treatment.
A double blind study chose patients with diastolic blood pressure of 90 to 129. After a year blood pressure in the treated group fell from 121 to 91.6. The five-year study begun in 1964, was stopped early when the placebo group did poorly. Results were published in 1967. A follow-up study looked at pressures between 90 and 114. It too found benefit to treatment. It was published in 1969. Today a dozen drugs are available. Diuretics remain among the most effective. Prehypertension is now defined as 120 to 139 over 80 to 89.
Monkeys fed a typical American diet (steak, mashed potatoes, and gravy) soon developed coronary artery disease. A bad diet could raise levels from 50 mg/dl to 2000/dl. Treatment is recommended today when total cholesterol exceeds 200 mg/dl. Three quarters of soldiers killed in the Korean War had plaque buildup at average age 22. Major blockage was found in 15%.
In 1944, Konrad Block learned how the body makes cholesterol from the acetate that feeds cells. A key enzyme in the production of LDL cholesterol was discovered in 1958. In the 1970s a study using cholestyramine to reduce cholesterol levels resulted in fewer heart attacks. Statin development followed. Merck found lovastatin but approval was delayed until 1987. The West Scotland Coronary Prevention Study using pravastatin found a 32% reduction in cardiovascular deaths. In 1994, a study of simvastatin found a 37% reduction in risk.
A chapter covers the homocysteine controversy. Investigation of homocysteine began late in the study. High levels of homocysteine gave increased vascular risk. That is associated with reduced vitamins B6, B12, and folic acid in the diet. They are removed when wheat is milled but readily available in vitamins. The finding remains to be confirmed.
In 2003, American Heart Association compared four popular diets: Atkins (low carb), Zone (moderate carbs), Ornish (very-low fat, vegetarian), and Weight Watchers (moderate fat). Up to half of participants dropped out but all who finished lost weight. They lowered their heart health risk by 14.7% (Weight Watchers), 12.3% (Atkins), 10.5% (Zone), and 6.6% (Ornish). All raised their HDL levels. In the US only 10% of males and 20% of females are at low risk; all the rest are at moderate to high risk. Public health efforts to educate about meat, dairy products, eggs, fat, and salt are strongly discredited by commercial interests.
The study also identified the health risks of smoking in 1962. Lung cancer from smoking was first reported in 1952. The tobacco industry worked hard to discredit results. Deaths from lung diseases and cancer partly masked the affect of smoking on heart disease. A study found the tobacco industry hooks 89% of lifetime smokers before age 19.
Hot dogs and cold cuts are high fat products. Nearly 90% of their calorie content is from fat. Crisco contains transfats. Canola or soybean oil are better choices. Butter, high in saturated fat, is still available but lard is now hard to find. Margarine is almost as bad due to its transfat content.
In 1999 a proposal arose to convert Framingham to a genome study called Framingham Genomic Medicine. Participants objected to misuse of their DNA and refused to sign releases. Boston University cancelled the genome study. Genetic studies have since been authorized. Factors affecting obesity and high blood pressure are under study.
This is a well written summary of the Framingham Study on factors affecting heart disease. The authors include background on related studies and their findings. References. Index.
- Reviewed in the United States on November 13, 2006What my cardiologist ordered to appreciate how one can best care for himself to live a longer life. Easy and very very interesting read. Great history pertaining to heart disease and it causes. May knock some sense into those with a foolish lifestyle.
- Reviewed in the United States on March 4, 2015I was looking for a lot more based on the title. I'll admit at this point I haven't finished the book; I'm about 40% through. I stopped because I felt I was wasting my time. I could really care less about the history of how Framingham got started, or if they wanted to do this hold it to one chapter. At the 40% point where I'm reading that only one doctor had an office and they go on to provide me with the size and shape of that space. Some may find this kind on nonsense interesting but I wanted the specifics of what they found from the studies and how their ideas of what caused heart disease modified over time. What does the size of an office have to do with unraveling the mysteries of heart disease, especially when they are still talking about this kind of nonsense 40% through the book?
And that's the problem with co-authored books; there is very little meat. I can almost visualize some marketing type approaching the doctor and telling him how much money he could make putting his name on a book. They go on to tell him it won't be much work on his
part and that the co-writer will be doing 95% of it. And, that shows in the final product.
I'll finish the book over time and hope to find the promise that the title made of "unraveling the mysteries of heart disease, or will I end up getting a full picture of how the doctors first bedroom was decorated?
3/8/2015 update
I finished the book and am still disappointed. It is primarily a history of the Framingham study with the politics, financial problems, personalities of the researchers, and without much to say about the actual detailed findings of the study. What you do get is a repeat of the well know risk factors for heart disease with a healthy helping of the saturated fat theory which includes a chapter on Keys. If your primary interest is history this book is for you. If on the other hand you're interested in the actual detailed results of the studies I would look elsewhere.
Oh yes, throughout the whole book they talk about fat and especially saturated fat the biggest evil in heart disease. The authors go on to say that they are glad that clinical trials are finally happening to point this fact out. They then cite Chris Gardners A to Z diet trial as a perfect example of making the point. However that isn't what Chris who is a vegetarian found. The authors say:
"compared four popular diets: Atkins (low carbohydrates), Zone (moderate carbohydrates), Ornish (very low-fat vegetarian), and Weight Watchers (moderate fat). Volunteers were assigned to one of the diets, then left on their own to follow the plan. They ran into the chronic dieter’s dilemma: half the volunteers on the Ornish and Atkins diets dropped out after a year, as did 35 percent of those on the Weight Watchers and Zone diets. Those who stuck with any program lost weight. And, using the Framingham risk models, they lowered their predicted heart disease risk scores by differing amounts: Weight Watchers, 14.7 percent; Atkins, 12.3 percent; Zone, 10.5 percent; and Ornish, 6.6 percent. All but the Ornish diet significantly increased levels of protective HDL cholesterol.25 Matching diet to lifestyle might help people stick with weight loss efforts. But the long-term effects of a high-protein, high-saturated-fat, low-carbohydrate diet remain unknown."
First, they got it wrong; the Atkins diet showed the greatest benefit in ALL risk factor and this particularly bothered the researcher since he was a vegetarian. Even if you take the number shown above, the Ornish diet which is lowest in all fats (under 10%) of all programs showed the WORST heart disease scores at 6.6 with the high fat Atkins at 12.3, which is 100% better than the ultra low fat Ornish. You can see a presentation by Chris Gartner on youtube of the A to Z study. It make interesting listening. So, the only clinical study noted was also a study that concludes the exact opposite of what the entire book is dedicated to. You either have to believe that Atkins is better for your heart than Ornish (Being vegan I don't believe this for a second) OR that risk factors in what are considered normal ranges are meaningless when it comes to heart disease. I'm not happy with either. That in the final analysis is why the book disappointed me. I guess that's the danger of having a Ghost Writer who has little idea about what they are writing about.
- Reviewed in the United States on July 27, 2014Good